KMID : 0882420110810030412
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Korean Journal of Medicine 2011 Volume.81 No. 3 p.412 ~ p.415
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A Case of Rheumatoid Arthritis Associated with Klinefelter¡¯s Syndrome
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Seo Mi-Ryoung
Cho Hyun-Jung Choi Hyo-Jin Baek Han-Joo Ahn Jeong-Yeal
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Abstract
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Klinefelter¡¯s syndrome is a disorder of sexual differentiation in males, characterized by the presence of two or more X-chromosomes, hypogonadism, and lack of secondary sexual characteristics. The association between Klinefelter¡¯s syndrome and systemic lupus erythematous has been described, while cases of rheumatoid arthritis associated with Klinefelter¡¯s syndrome are rare. We report the first Korean case: a 29-year-old man with Klinefelter¡¯s syndrome who developed rheumatoid arthritis. The sex hormone imbalance might have influenced the onset and course of his disease.
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KEYWORD
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Klinefelter¡¯s syndrome, Rheumatoid arthritis, Sex hormones
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